The Finished DNA Sequence
of Human Chromosome 12

Nature, 2006, 440:346-351

( Finished Chr 12 sequence GenBank accession #: NC_000012 )

 
Corresponding author:

Steven Scherer (sscherer@bcm.tmc.edu)
Human Genome Sequencing Center, Baylor College of Medicine

Complete author and affiliation list

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Abstract:

Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing ~4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.



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Complete Author & Affiliation List:

Steven E. Scherer1, Donna M. Muzny1, Christian J. Buhay1, Rui Chen1, Andrew Cree1, Yan Ding1, Shannon Dugan-Rocha1, Rachel Gill1, Preethi Gunaratne1, R. Alan Harris1, Alicia C. Hawes1, Judith Hernandez1, Anne V. Hodgson1, Jennifer Hume1, Andrew Jackson1, Ziad Mohid Khan1, Christie Kovar-Smith1, Lora R. Lewis1, Ryan J. Lozado1, Michael L. Metzker1, Aleksandar Milosavljevic1, George R. Miner1, Kate T. Montgomery2, Margaret B. Morgan1, Lynne V. Nazareth1, Graham Scott1, Erica Sodergren1, Xing-Zhi Song1, David Steffen1, Ruth C. Lovering3, David A. Wheeler1, Kim C. Worley1, Yi Yuan1, Zhengdong Zhang1, Charles Q. Adams1, M. Ali Ansari-Lari1, Mulu Ayele1, Mary J. Brown1, Guan Chen1, Zhijian Chen1, Kerstin P. Clerc-Blankenburg1, Clay Davis1, Oliver Delgado1, Huyen H. Dinh1, Heather Draper1, Manuel L. Gonzalez-Garay1, Paul Havlak1, Laronda R. Jackson1, Leni S. Jacob1, Susan H. Kelly1, Li Li2, Zhangwan Li1, Jing Liu1, Wen Liu1, Jing Lu1, Manjula Maheshwari1, Bao-Viet Nguyen1, Geoffrey O. Okwuonu1, Shiran Pasternak1, Lesette M. Perez1, Farah J. H. Plopper1, Jireh Santibanez1, Hua Shen1, Paul E. Tabor1, Daniel Verduzco1, Lenee Waldron1, Qiaoyan Wang1, Gabrielle A. Williams1, JingKun Zhang1, Jianling Zhou1, David Nelson1, Raju Kucherlapati2, George Weinstock1 and Richard A. Gibbs1

and

The Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team:
Carlana C. Allen4, Anita G. Amin4, Vivian Anyalebechi4, Michael Bailey4, Joseph A. Barbaria4, Kesha E. Bimage4, Nathaniel P. Bryant4, Paula E. Burch4, Carrie E. Burkett4, Kevin L. Burrell4, Eliana Calderon4, Veronica Cardenas4, Kelvin Carter4, Kristal Casias4, Iracema Cavazos4, Sandra R. Cavazos4, Heather Ceasar4, Joseph Chacko4, Sheryl N. Chan4, Dean Chavez4, Constantine Christopoulos4, Joseph Chu4, Raynard Cockrell4, Caroline D. Cox4, Michelle Dang4, Stephanie R. Dathorne4, Robert David4, Candi Mon'Et Davis4, Latarsha Davy-Carroll4, Denise R. Deshazo4, Jeremy E. Donlin4, Lisa D'Souza4, Kristy A. Eaves1, Amy Egan4, Alexandra J. Emery-Cohen4, Michael Escotto4, Nicole Flagg4, Lisa D. Forbes4, Abdul M. Gabisi4, Melissa Garza4, Cerissa Hamilton4, Nicholas Henderson4, Omar Hernandez4, Sandra Hines4, Marilyn E. Hogues4, Mei Huang4, DeVincent G. Idlebird4, Rudy Johnson4, Angela Jolivet4, Sally Jones4, Ryan Kagan4, Laquisha M. King4, Belita Leal4, Heather Lebow4, Sandra Lee4, Jaclyn M. LeVan4, Lakeshia C. Lewis4, Pamela London4, Lorna M. Lorensuhewa4, Hermela Loulseged4, Demetria A. Lovett4, Alice Lucier4, Raymond L. Lucier4, Jie Ma4, Renita C. Madu4, Patricia Mapua4, Ashley D. Martindale4, Evangelina Martinez4, Elizabeth Massey4, Samantha Mawhiney4, Michael G. Meador4, Sylvia Mendez4, Christian Mercado4, Iracema C. Mercado4, Christina E. Merritt4, Zachary L. Miner4, Emmanuel Minja4, Teresa Mitchell4, Farida Mohabbat4, Khatera Mohabbat4, Baize Montgomery4, Niki Moore4, Sidney Morris4, Mala Munidasa4, Robin N. Ngo4, Ngoc B. Nguyen4, Elizabeth Nickerson4, Ogechi O. Nwaokelemeh4, Stanley Nwokenkwo4, Melissa Obregon4, Maryann Oguh4, Njideka Oragunye4, Rodolfo J. Oviedo4, Bridgette J. Parish4, David N. Parker4, Julia Parrish4, Kenya L. Parks4, Heidie A. Paul4, Brett A. Payton4, Agapito Perez4, William Perrin4, Adam Pickens4, Eltrick L. Primus4, Ling-Ling Pu4, Maria Puazo4, Miyo M. Quiles4, Juana B. Quiroz4, Dina Rabata4, Kacy Reeves4, San Juana Ruiz4, Hongmei Shao4, Ida Sisson4, Titilola Sonaike4, Richard P. Sorelle4, Angelica E. Sutton4, Amanda F. Svatek4, Leah Anne Svetz4, Kavitha S. Tamerisa4, Tineace R. Taylor4, Brian Teague4, Nicole Thomas4, Rachel D. Thorn4, Zulma Y. Trejos4, Brenda K. Trevino4, Ogechi N. Ukegbu4, Jeremy B. Urban4, Lydia I. Vasquez4, Virginia A. Vera4, Donna M. Villasana4, Ling Wang4, Stephanie Ward-Moore4, James T. Warren4, Xuehong Wei4, Flower White4, Angela L. Williamson4, Regina Wleczyk4, Hailey S. Wooden4, Steven H. Wooden4, Jennifer Yen4, Lillienne Yoon4, Vivienne Yoon4 and Sara E. Zorrilla4

Affiliations:

  1. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
  2. Harvard Medical School-Partners Healthcare Center for Genetics and Genomics, Boston, Massachusetts 02115, USA
  3. HUGO Gene Nomenclature Committee, The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
  4. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA

 

 


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