Gene expression study of cancer

Biomarker discovery from gene expression and serum MALDI-TOF data - TENTATIVE. Discovery of prognostic and predictive biomarkers from gene expression and mass spectrometry data using feature selection and unsupervised learning.

Focus paper (see also Comp Lab exercise for this week):

Expression profiles of osteosarcoma that can predict response to chemotherapy. Cancer Res. 2005 Sep 15;65(18):8142-50. PMID: 16166288 [PubMed - indexed for MEDLINE]

Other relevant papers:

Classification of sarcomas using bioinformatics and molecular profiling. Curr Pharm Biotechnol. 2007 Apr;8(2):83-91. Review. PMID: 17430156 [PubMed - indexed for MEDLINE]

Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics. 2006 Jun;6(11):3426-35. PMID: 16673437 [PubMed - indexed for MEDLINE]

Prof. Chris Man