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1-29-09: Computational laboratory
Mr. Chris Miller -
camiller@bcm.edu
Jian Li -
jianl@bcm.edu
Important Links:
01-29-10 lecture slides
Data files for homework
Download GSEA
Download R statistical package
Homework assignment
Lab Lecture Slides
Presentation Webcast
Insulin-like growth factor I (IGF-I) activates gene transcription programs strongly associated with poor breast cancer prognosis. (2008). Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, and Lee AV. Journal of Clinical Oncology. 26:4078-4085
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. PMID: 16199517
A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors.(2007). Creighton CJ. Oncogene. 26:4648-4655.
Oncogenic pathway signatures in human cancers as a guide to targeted therapies. (2006). Bild AH, et al. Nature 439, 353-357.
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